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A reduction in mitochondrial DNA is correlated with IR, hyperandrogenemia, and polycystic ovarian morphology in women with PCOS (115117)

However, PAI-1 carbonylation has been demonstrated to influence its functional activity and structural stability [38], therefore carbonylated PAI-1 may exhibit reduced activity, and we hypothesize that it could trigger a compensatory mechanism leading to an increase in its overall concentration observed in our cohort

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The effects of both treatments can come together and complement

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